Kate Makrigiannis
I build great products,
lead strong teams, and make
delivery predictable
14 years across healthcare, defense, and enterprise. Looking for my next full-time role, and open to consulting.
“Kate is impressive - she provided value right away. She's a 'hell-yes' type of talent.”
Featured work
Case studies from healthcare, defense, enterprise, and AI.
Building an AI Practice and 340+ Skill Agent System at Artium
Artium · 2025-2026
Led product for Artium's AI Practice, creating Skillet, a 340+ skill AI agent system powering reusable consulting workflows. Also led product on Helia, a clinical trial startup simulator for a $2.7B CRO client.
0-to-1Launching FLUXX: An AI-Powered Menopause Platform
FLUXX Health · 2024-2025
Fractional Head of Product for FLUXX, a clinician-led menopause education platform. Delivered MVP in under six months with AI-driven phase scoring, trauma-aware UX, and a sustainable team operating model.
0-to-1Designing a Wellness MVP for Biomarker-Driven Preventative Care
Sperity Health · 2024 - 2025
Served as Fractional Director of Product to lead Sperity Health from vaporware to a functioning, HIPAA-compliant MVP. Built the roadmap, treatment logic, product team, and app experience for members to understand diagnostics, track progress, and access elite care.
From the playbook
Practices I teach every team I work with.
Getting Unstuck
A diagnostic framework for teams that know something's wrong but can't name it
Use this when: Your team knows something is off but can't articulate what
Story Writing
Writing stories that developers can actually build from
Use this when: Your stories keep growing mid-sprint or developers keep asking 'what do you actually want?'
AI Maturity
A structured way to assess where your team actually is with AI - and what to work on next
Use this when: Your team is using AI tools but you're not sure if it's working or what to invest in next
Delivery Diagnostics
How to figure out why your team is slow before deciding what to change
Use this when: Velocity is declining, stories keep carrying over, or something feels off but you can't explain why
Recent writing
On product leadership, AI strategy, and building teams that ship.
May 30, 2026
AI Product Strategy in Healthcare: What Changes When the Stakes Are Clinical
Healthcare AI products fail when teams apply consumer AI strategy to clinical domains. The job is not prediction. The job is trust. Three principles for getting it right.
May 29, 2026
Fractional vs. Full-Time Product Leader: What's Right for Your Team?
Fractional product leaders are faster, cheaper, and lower risk. Full-time hires build deeper context and culture. Here is how to decide which one your team needs right now.
May 29, 2026
How Much Does a Fractional Product Manager Cost?
Fractional product managers typically cost $150-350 per hour or $5,000-20,000 per month. But the real question is not what it costs -- it is what it costs you to not have one.
Let's talk about what
you're building
I'm looking for my next full-time role and have a spot for a new consulting engagement. If you're hiring or need hands-on help, I'd love to hear from you.
Get in touch